St. John's Wort and Cyclosporine: Can You Take Them Together?
Here's what FDA drug labeling and NIH supplement data show.
Interaction Found
What happens: CYP3A4 induction reduces blood levels of immunosuppressants, risking organ rejection.
What to do: Contraindicated in transplant patients.
Source: FDA-approved drug labeling and NIH Office of Dietary Supplements fact sheets.
Learn more
Cyclosporine — full safety profile, side effects, and all known interactions.
St. John's Wort — supplement labels containing this ingredient.
Frequently asked questions
Can I take St. John's Wort with Cyclosporine?
Contraindicated in transplant patients.
What happens if you take St. John's Wort and Cyclosporine together?
CYP3A4 induction reduces blood levels of immunosuppressants, risking organ rejection.
What should I do if I take both?
Contraindicated in transplant patients. Always consult your healthcare provider before combining supplements and medications.
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.