Melatonin and Diazepam: Can You Take Them Together?

Here's what FDA drug labeling and NIH supplement data show.

MILD

Interaction Found

What happens: Additive sedation effect.

What to do: Use caution when combining. Start with low melatonin dose.

Source: FDA-approved drug labeling and NIH Office of Dietary Supplements fact sheets.

Learn more

Diazepam — full safety profile, side effects, and all known interactions.

Melatonin — supplement labels containing this ingredient.

Frequently asked questions

Can I take Melatonin with Diazepam?

Use caution when combining. Start with low melatonin dose.

What happens if you take Melatonin and Diazepam together?

Additive sedation effect.

What should I do if I take both?

Use caution when combining. Start with low melatonin dose. Always consult your healthcare provider before combining supplements and medications.

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.