Ketoconazole Cream and Trazodone Hydrochloride: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

When ketoconazole cream and trazodone are used together, trazodone may not work as well. This happens because ketoconazole can change how your body processes trazodone. This could make your depression symptoms harder to control.

What to do: Talk to your doctor or pharmacist about using these medicines together. Do not stop taking either medicine without talking to your doctor first. Your doctor may need to adjust your dose or watch you more carefully.

Source: FDA-approved drug labeling via openFDA

About These Medications

Ketoconazole Cream — View full safety profile, side effects, and all known interactions.

Trazodone Hydrochloride — View full safety profile, side effects, and all known interactions.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.