St. John's Wort and Norethindrone: Can You Take Them Together?
Here's what FDA drug labeling and NIH supplement data show.
Interaction Found
What happens: Enzyme induction increases metabolism of hormonal contraceptives, potentially causing breakthrough bleeding or unplanned pregnancy.
What to do: Use additional contraception or avoid St. John's Wort.
Source: FDA-approved drug labeling and NIH Office of Dietary Supplements fact sheets.
Learn more
Norethindrone — full safety profile, side effects, and all known interactions.
St. John's Wort — supplement labels containing this ingredient.
Frequently asked questions
Can I take St. John's Wort with Norethindrone?
Use additional contraception or avoid St. John's Wort.
What happens if you take St. John's Wort and Norethindrone together?
Enzyme induction increases metabolism of hormonal contraceptives, potentially causing breakthrough bleeding or unplanned pregnancy.
What should I do if I take both?
Use additional contraception or avoid St. John's Wort. Always consult your healthcare provider before combining supplements and medications.
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.