digoxin
Brand names: Digoxin
# Overview of Digoxin Digoxin is a heart medication that doctors prescribe to help people with certain heart problems. It works by making the heart beat more strongly and at a steadier rate. Doctors use digoxin mainly to treat heart failure, a condition where the heart doesn't pump blood as well as it should. The medication can also help control irregular heartbeats. By improving how the heart works, digoxin helps the body get the oxygen and blood it needs to stay healthy. Because digoxin is a powerful medicine, it requires careful monitoring and dosing by a doctor. It's very important not to take more digoxin than prescribed and to take it exactly as directed, since too much can cause serious side effects. Additionally, digoxin can interact with many other medications, so your doctor needs to know about all the medicines you take. You should never start, stop, or change the dose of any other drugs without talking to your doctor first. Regular blood tests may be needed to make sure the amount of digoxin in your body is safe and working properly.
Known Interactions
7 DRUG INTERACTIONS Digoxin has a narrow therapeutic index, increased monitoring of serum digoxin concentrations and for potential signs and symptoms of clinical toxicity is necessary when initiating, adjusting, or discontinuing drugs that may interact with digoxin. Prescribers should consult the prescribing information of any drug which is co-prescribed with digoxin for potential drug interaction information. PGP Inducers/Inhibitors: Drugs that induce or inhibit PGP have the potential to alter digoxin pharmacokinetics. ( 7.1 ) The potential for drug-drug interactions must be considered prior to and during drug therapy. See full prescribing information. ( 7.2 , 7.3 , 12.3 ) 7.1 P-Glycoprotein (PGP) Inducers/Inhibitors Digoxin is a substrate of P-glycoprotein, at the level of intestinal absorption, renal tubular section and biliary–intestinal secretion. Therefore, drugs that induce/inhibit P-glycoprotein have the potential to alter digoxin pharmacokinetics. 7.2 Pharmacokinetic Drug Inte
Source: FDA-approved drug labeling via openFDA
Most Reported Side Effects (FAERS)
- DYSPNOEA6,064 reports
- NAUSEA4,754 reports
- DIZZINESS4,442 reports
- FATIGUE4,176 reports
- ATRIAL FIBRILLATION3,978 reports
- DIARRHOEA3,741 reports
- ASTHENIA3,618 reports
- DEATH3,397 reports
- VOMITING3,363 reports
- HYPOTENSION3,169 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Check interactions with digoxin:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.