Vitamin D and Hydrochlorothiazide: Can You Take Them Together?

Here's what FDA drug labeling and NIH supplement data show.

MILD

Interaction Found

What happens: Both vitamin D and thiazides increase calcium levels, risking hypercalcemia.

What to do: Monitor calcium levels periodically.

Source: FDA-approved drug labeling and NIH Office of Dietary Supplements fact sheets.

Learn more

Hydrochlorothiazide — full safety profile, side effects, and all known interactions.

Vitamin D — supplement labels containing this ingredient.

Frequently asked questions

Can I take Vitamin D with Hydrochlorothiazide?

Monitor calcium levels periodically.

What happens if you take Vitamin D and Hydrochlorothiazide together?

Both vitamin D and thiazides increase calcium levels, risking hypercalcemia.

What should I do if I take both?

Monitor calcium levels periodically. Always consult your healthcare provider before combining supplements and medications.

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.