hydrochlorothiazide

Brand names: Lisinopril and Hydrochlorothiazide

# Hydrochlorothiazide: What You Should Know Hydrochlorothiazide, often called HCTZ, is a water pill that helps lower blood pressure and reduce swelling in your body. It works by helping your kidneys remove extra salt and water through urine. Doctors prescribe this medication to treat high blood pressure and to help people with certain conditions that cause fluid buildup in their legs, ankles, or other parts of the body. By lowering blood pressure, this medicine helps protect your heart and prevent serious health problems like heart attacks and strokes. Before taking hydrochlorothiazide, it's important to know some safety information. Tell your doctor if you're taking other blood pressure medicines, especially ACE inhibitors like lisinopril, because combining them can sometimes cause your blood pressure to drop too much. Since this medicine makes you urinate more, drink plenty of water and eat healthy foods with potassium, like bananas and oranges, to stay balanced. You should have regular check-ups with your doctor while taking this medication so they can monitor how well it's working and make sure you're not having any problems. If you experience dizziness, weakness, or unusual tiredness, contact your doctor right away.

Known Interactions

Drug Interactions Lisinopril Hypotension - Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with lisinopril. The possibility of hypotensive effects with lisinopril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with lisinopril. If it is necessary to continue the diuretic, initiate therapy with lisinopril at a dose of 5 mg daily, and provide close medical supervision after the initial dose for at least two hours and until blood pressure has stabilized for at least an additional hour. (See WARNINGS , and DOSAGE AND ADMINISTRATION .) When a diuretic is added to the therapy of a patient receiving lisinopril, an additional antihypertensive effect is usually observed (See DOSAGE AND ADMINISTRATION .) Non-steroidal Anti-inflammatory Agents Including Select

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • NAUSEA13,416 reports
  • FATIGUE13,396 reports
  • DRUG INEFFECTIVE13,040 reports
  • DIARRHOEA11,435 reports
  • DIZZINESS11,013 reports
  • HEADACHE10,466 reports
  • DYSPNOEA10,280 reports
  • PAIN10,092 reports
  • ARTHRALGIA7,963 reports
  • ASTHENIA7,773 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with hydrochlorothiazide:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.