Hydrochlorothiazide: Uses, Side Effects, and Drug Interactions
Brand names: Lisinopril and Hydrochlorothiazide
# Hydrochlorothiazide: What You Should Know Hydrochlorothiazide, often called HCTZ, is a water pill that helps lower blood pressure and reduce swelling in your body. It works by helping your kidneys remove extra salt and water through urine. Doctors prescribe this medication to treat high blood pressure and to help people with certain conditions that cause fluid buildup in their legs, ankles, or other parts of the body. By lowering blood pressure, this medicine helps protect your heart and prevent serious health problems like heart attacks and strokes. Before taking hydrochlorothiazide, it's important to know some safety information. Tell your doctor if you're taking other blood pressure medicines, especially ACE inhibitors like lisinopril, because combining them can sometimes cause your blood pressure to drop too much. Since this medicine makes you urinate more, drink plenty of water and eat healthy foods with potassium, like bananas and oranges, to stay balanced. You should have regular check-ups with your doctor while taking this medication so they can monitor how well it's working and make sure you're not having any problems. If you experience dizziness, weakness, or unusual tiredness, contact your doctor right away.
Known Interactions (9)
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Check Now ↓Most Reported Side Effects (FAERS)
- NAUSEA13,416 reports
- FATIGUE13,396 reports
- DRUG INEFFECTIVE13,040 reports
- DIARRHOEA11,435 reports
- DIZZINESS11,013 reports
- HEADACHE10,466 reports
- DYSPNOEA10,280 reports
- PAIN10,092 reports
- ARTHRALGIA7,963 reports
- ASTHENIA7,773 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (5)
- Class II
Unichem Pharmaceuticals USA Inc. · January 21, 2026
Bisoprolol Fumarate and Hydrochlorothiazide tablets, USP, 2.5 mg/6.25 mg, 100-count bottle, Rx Only, Manufactured by: UNICHEM LABORATORIS LTD., Pilerne Ind. Estate, Pilerne, Bardez, Goa 403 511, IndiacGMP Deviations: recall due to not meeting the N-Nitroso Bisoprolol impurity specification limits.
- Class III
Glenmark Pharmaceuticals Inc., USA · November 21, 2025
Bisoprolol Fumarate and Hydrochlorothiazide Tablets, USP, 2.5 mg/6.25 mg, packaged as (a) 30-count bottles, NDC-68462-878-30; (b) 100-count bottle, NDC-68462-878-01; (c) 500-count bottles, NDC-68462-8Cross Contamination with Other Products: Testing of reserve samples showed presence of traces of ezetimibe
- Class II
Lupin Pharmaceuticals Inc. · June 20, 2025
Lisinopril and Hydrochlorothiazide Tablets USP 20mg/12.5mg, 100-count bottles, Rx only, Mfg for: Lupin Pharmaceuticals, Inc. Baltimore, MD 21202, Manufactured by: Lupin Limited Nagpur-441 108, INDIA,Product Mix Up: This product is being recalled because of a complaint received that a sealed bottle of lisinopril and hydrochlorothiazide tablets 20mg/12.5 mg had a foreign tablet identified as atazanavir and ritonavir tablet 300mg/100mg.
- Class II
MACLEODS PHARMA USA, INC · May 7, 2024
Losartan Potassium and Hydrochlorothiazide Tablets, USP 50mg /12.5 mg, 1000-count bottle, Rx only, Manufactured for: Macleods Pharma USA, Inc. Princeton, NJ 08540, Manufactured by: Macleods PharmaceutPresence of foreign substance: plastic-like substance.
- Class II
CARDINAL HEALTHCARE · January 26, 2022
Lisinopril and Hydrochlorothiazide Tablets USP, 10mg/12.5mg, Rx only, 100 Tablets per bottles, Manufactured for: Lupin Pharmaceuticals, Inc., Baltimore, Maryland 21202; Manufactured by: Lupin Limited,CGMP Deviations: Products were exposed to temperatures outside of the products labeled storage conditions.
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
Supplement Interactions (1)
These dietary supplements may interact with Hydrochlorothiazide. Always consult your healthcare provider.
- mildvitamin d
Both vitamin D and thiazides increase calcium levels, risking hypercalcemia.
Monitor calcium levels periodically.
Check interactions with Hydrochlorothiazide:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.