St. John's Wort and Sertraline: Can You Take Them Together?
Here's what FDA drug labeling and NIH supplement data show.
Interaction Found
What happens: Both increase serotonin levels, risking serotonin syndrome (agitation, rapid heart rate, high blood pressure).
What to do: Do not combine. Consult your doctor before using St. John's Wort if you take any antidepressant.
Source: FDA-approved drug labeling and NIH Office of Dietary Supplements fact sheets.
Learn more
Sertraline — full safety profile, side effects, and all known interactions.
St. John's Wort — supplement labels containing this ingredient.
Frequently asked questions
Can I take St. John's Wort with Sertraline?
Do not combine. Consult your doctor before using St. John's Wort if you take any antidepressant.
What happens if you take St. John's Wort and Sertraline together?
Both increase serotonin levels, risking serotonin syndrome (agitation, rapid heart rate, high blood pressure).
What should I do if I take both?
Do not combine. Consult your doctor before using St. John's Wort if you take any antidepressant. Always consult your healthcare provider before combining supplements and medications.
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.