Sertraline: Uses, Side Effects, and Drug Interactions
Brand names: Sertraline Hydrochloride
# Overview of Sertraline Sertraline is a medicine used to treat depression, anxiety, and other mental health conditions. Doctors prescribe it to help people feel better when they're struggling with their mood or worried feelings. The medicine works by affecting chemicals in the brain that control how we feel. Many people take sertraline every day as part of their treatment plan to feel more like themselves and get back to enjoying their normal activities. It's important to know some safety information about sertraline. If you're already taking other medicines, especially blood thinners or heart medications, you should tell your doctor because sertraline can interact with them in ways that might not be safe. You shouldn't stop taking sertraline suddenly without talking to your doctor first, because this could cause problems. Some people taking this medicine might have thoughts of harming themselves, especially when they first start taking it or when the dose changes, so it's important to watch for warning signs and talk to a doctor if you notice anything concerning. Always take sertraline exactly as your doctor tells you to, and let them know if you experience any side effects or have questions about your treatment.
Known Interactions (15)
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Check Now ↓Most Reported Side Effects (FAERS)
- NAUSEA13,398 reports
- DRUG INEFFECTIVE13,249 reports
- FATIGUE12,443 reports
- HEADACHE10,802 reports
- ANXIETY10,071 reports
- DIARRHOEA9,973 reports
- DIZZINESS9,347 reports
- DEPRESSION9,309 reports
- PAIN8,086 reports
- OFF LABEL USE8,014 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (2)
- Class II
Lupin Pharmaceuticals Inc. · November 5, 2025
Sertraline Hydrochloride Tablets USP, 100 mg, 90 Tablets bottles, Rx Only, Manufactured by: Lupin Pharmaceuticals, Inc., Naples, FL 34108, NDC 68180-353-09.Defective container - seal not adhering to bottles
- Class II
Legacy Pharmaceutical Packaging LLC · December 11, 2023
Sertraline Tablets, USP 100 mg, 30 tablets per bottle, Distributed by: Wal-Mart, Bentonville, AR 72716, Manufactured for: Cipla USA, Inc., Warren, NJ 07059, Packaged by: Legacy Pharmaceutical PackaginCGMP Deviations: Inadequate line clearance which may result in a potential comingling of product.
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
Supplement Interactions (1)
These dietary supplements may interact with Sertraline. Always consult your healthcare provider.
- severest. john's wort
Both increase serotonin levels, risking serotonin syndrome (agitation, rapid heart rate, high blood pressure).
Do not combine. Consult your doctor before using St. John's Wort if you take any antidepressant.
Check interactions with Sertraline:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.