sertraline

Brand names: Sertraline Hydrochloride

# Overview of Sertraline Sertraline is a medicine used to treat depression, anxiety, and other mental health conditions. Doctors prescribe it to help people feel better when they're struggling with their mood or worried feelings. The medicine works by affecting chemicals in the brain that control how we feel. Many people take sertraline every day as part of their treatment plan to feel more like themselves and get back to enjoying their normal activities. It's important to know some safety information about sertraline. If you're already taking other medicines, especially blood thinners or heart medications, you should tell your doctor because sertraline can interact with them in ways that might not be safe. You shouldn't stop taking sertraline suddenly without talking to your doctor first, because this could cause problems. Some people taking this medicine might have thoughts of harming themselves, especially when they first start taking it or when the dose changes, so it's important to watch for warning signs and talk to a doctor if you notice anything concerning. Always take sertraline exactly as your doctor tells you to, and let them know if you experience any side effects or have questions about your treatment.

Known Interactions

Drug Interactions Potential Effects of Coadministration of Drugs Highly Bound to Plasma Proteins –Because sertraline is tightly bound to plasma protein, the administration of sertraline hydrochloride to a patient taking another drug which is tightly bound to protein (e.g., warfarin, digitoxin) may cause a shift in plasma concentrations potentially resulting in an adverse effect. Conversely, adverse effects may result from displacement of protein bound sertraline hydrochloride by other tightly bound drugs. In a study comparing prothrombin time AUC (0-120 hr) following dosing with warfarin (0.75 mg/kg) before and after 21 days of dosing with either sertraline hydrochloride (50-200 mg/day) or placebo, there was a mean increase in prothrombin time of 8% relative to baseline for sertraline hydrochloride compared to a 1% decrease for placebo (p<0.02). The normalization of prothrombin time for the sertraline hydrochloride group was delayed compared to the placebo group. The clinical significa

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • NAUSEA13,398 reports
  • DRUG INEFFECTIVE13,249 reports
  • FATIGUE12,443 reports
  • HEADACHE10,802 reports
  • ANXIETY10,071 reports
  • DIARRHOEA9,973 reports
  • DIZZINESS9,347 reports
  • DEPRESSION9,309 reports
  • PAIN8,086 reports
  • OFF LABEL USE8,014 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with sertraline:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.