Clopidogrel and Fluoxetine: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking clopidogrel with fluoxetine increases your bleeding risk. Fluoxetine is an SSRI medicine used for depression and anxiety. When combined with clopidogrel (a blood thinner), it makes bleeding more likely. This could cause excessive bleeding from cuts or inside your body.

What to do: Talk to your doctor or pharmacist about taking these medicines together. Do not stop either medicine on your own. Your doctor may monitor you more closely or adjust your dosage if needed.

Source: FDA-approved drug labeling via openFDA

About These Medications

Clopidogrel — View full safety profile, side effects, and all known interactions.

Fluoxetine — View full safety profile, side effects, and all known interactions.

Other interactions with Clopidogrel

SEVEREwarfarinMODERATEomeprazoleMODERATEescitalopramMODERATEpantoprazoleMODERATEibuprofenMODERATEtrazodone

Other interactions with Fluoxetine

MODERATEmetoprololMODERATElosartanMODERATEsertralineMODERATEtramadolMODERATEibuprofenMODERATEwarfarin

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.