Bupropion: Uses, Side Effects, and Drug Interactions
Brand names: buPropion Hydrochloride XL
# Understanding Bupropion Bupropion is a medication that doctors prescribe to help people with depression and to help smokers quit smoking. It works by changing the levels of certain chemicals in your brain that affect your mood and behavior. Unlike some other depression medicines, bupropion can actually help people feel more energized and focused rather than making them sleepy. It comes in different forms that you take by mouth, usually once or twice a day depending on which type your doctor prescribes. There are some important safety things to know about bupropion. This medicine can increase your risk of seizures, especially if you take high doses, so tell your doctor if you have ever had seizures or head injuries. It's also important to let your doctor know about all other medicines you take, because bupropion can interact with them—for example, it can increase the levels of certain depression and antipsychotic medicines in your body. You should never suddenly stop taking bupropion without talking to your doctor first. Like other depression medicines, bupropion may increase thoughts of suicide in young people, so watch for changes in mood or behavior and talk to your doctor right away if anything seems wrong.
Known Interactions (8)
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Check Now ↓Most Reported Side Effects (FAERS)
- DRUG INEFFECTIVE12,772 reports
- NAUSEA11,505 reports
- FATIGUE9,694 reports
- HEADACHE9,687 reports
- DEPRESSION8,444 reports
- ANXIETY7,573 reports
- DIZZINESS7,528 reports
- PAIN6,600 reports
- OFF LABEL USE6,296 reports
- INSOMNIA5,776 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (3)
- Class II
Graviti Pharmaceuticals Private Limited · September 15, 2025
Bupropion Hydrochloride Extended-Release Tablets USP (XL), 300 mg, 30-count bottles, Rx Only, Mfd. by: Graviti Pharmaceuticals Private Limited, Sangareddy, Telangana, India, Dist. by: Rising Phar, NDCFailed Tablet/Capsule Specifications
- Class II
Amerisource Health Services LLC · June 24, 2024
buPROPion Hydrochloride Extended-release Tablets USP (XL) Once-Daily, 150 mg, 100 Tablets (10 x 10) per carton, Rx Only, Distributed by: American Health Packaging, Columbus, Ohio 43217, NDC: 60687-782Failed Dissolution Specifications; the product is dissolving faster than the specified limits.
- Class II
Rising Pharma Holding, Inc. · December 29, 2023
buPROPion Hydrochloride Extended-Release Tablets, USP (XL) 150mg, 30-count bottles, Rx Only, Manufactured for: Rising Pharma Holdings, Inc. East Brunswick, NJ 08816 Manufactured by: Graviti PharmaceutPresence of Foreign Tablets/Capsules
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
Check interactions with Bupropion:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.