Bupropion and Sertraline: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Bupropion can increase the amount of sertraline in your body. This happens because bupropion affects how your body breaks down sertraline. Too much sertraline can cause side effects like shakiness, confusion, or rapid heartbeat.

What to do: Tell your doctor you take both medications. Your doctor may need to lower your sertraline dose or monitor you more closely. Do not stop either medication without talking to your doctor first.

Source: FDA-approved drug labeling via openFDA

About These Medications

Bupropion — View full safety profile, side effects, and all known interactions.

Sertraline — View full safety profile, side effects, and all known interactions.

Other interactions with Bupropion

MODERATEmetoprololMODERATEomeprazoleMODERATElosartanMODERATEtramadolMODERATEclopidogrelMODERATEfluoxetine

Other interactions with Sertraline

MODERATEvenlafaxineMODERATEwarfarinMODERATElosartanMODERATElevothyroxineMODERATEatenololMODERATEibuprofen

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.