Trazodone: Uses, Side Effects, and Drug Interactions
Brand names: Trazodone Hydrochloride
# Trazodone: What You Need to Know Trazodone is a medication doctors prescribe to treat depression. It works by helping balance chemicals in your brain that affect your mood. When you take trazodone, it can help reduce sadness, anxiety, and other symptoms of depression. Many people find that this medicine helps them feel better and improves their sleep, since it can make you drowsy. Your doctor will tell you the right dose for your situation, and it's important to take it exactly as prescribed. There are some important safety things to remember when taking trazodone. Don't mix it with alcohol or other drugs that make you sleepy, because trazodone can make these effects stronger and more dangerous. Tell your doctor about all other medicines you take, especially blood thinners like warfarin or heart medications like digoxin, because trazodone might change how these drugs work in your body. Never take trazodone if you're also taking a type of antidepressant called MAOIs, and wait at least 14 days after stopping MAOIs before starting trazodone. Common side effects include feeling sleepy or dizzy, but contact your doctor if you have any concerning symptoms or if the medicine doesn't seem to be helping.
Known Interactions (9)
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Check Now ↓Most Reported Side Effects (FAERS)
- DRUG INEFFECTIVE1,181 reports
- FATIGUE1,129 reports
- NAUSEA1,098 reports
- HEADACHE909 reports
- PAIN808 reports
- DIARRHOEA793 reports
- OFF LABEL USE711 reports
- VOMITING676 reports
- INSOMNIA673 reports
- DEPRESSION656 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (2)
- Class II
Granules Pharmaceuticals Inc. · January 26, 2026
Trazodone Hydrochloride, USP, 50 mg, 100-Count Bottle, Rx only, Manufactured by: Granules India Limited, Hyderabad, 500 081, India, Manufactured for: Granules Pharmaceuticals Inc., Chantilly, VA 20151Presence of Foreign Tablets/Capsules
- Class III
Zydus Pharmaceuticals (USA) Inc · December 19, 2025
traZODONE Hydrochloride Tablets, USP, 100mg, 1,000 Tablets, Rx only, Manufactured by: Zydus Lifesciences Ltd., India, Distributed by: Zydus Pharmaceuticals (USA) Inc., Pennington, NJ 08534, NDC 68382-Failed Tablet/Capsule Specifications: Product complaint received that some tablets had a dent on the plain side of the tablet surface.
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.