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oxycodone and trazodone — Drug Interaction

Can you take oxycodone and trazodonetogether? Here's what FDA data shows.

SEVERE

Interaction Found

Taking oxycodone with trazodone together can be dangerous. These drugs can cause serotonin syndrome (confusion, rapid heartbeat, high fever) or make oxycodone too strong, leading to serious breathing problems or coma.

What to do: Talk to your doctor or pharmacist before taking these medicines together. Do not stop either medication on your own. Your doctor may adjust your doses or suggest safer alternatives.

Source: FDA-approved drug labeling via openFDA

About These Medications

oxycodone — View full safety profile, side effects, and all known interactions.

trazodone — View full safety profile, side effects, and all known interactions.

Other interactions with oxycodone

SEVEREgabapentinSEVEREtramadolSEVEREalprazolamMODERATEomeprazoleMODERATElosartanMODERATEcyclobenzaprine

Other interactions with trazodone

MODERATElosartanMODERATEtramadolMODERATEwarfarinMODERATEclopidogrelMILDibuprofenMILDnaproxen

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.