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tramadol and trazodone — Drug Interaction

Can you take tramadol and trazodonetogether? Here's what FDA data shows.

MODERATE

Interaction Found

Taking tramadol with trazodone together can cause serotonin syndrome, which includes symptoms like confusion, rapid heartbeat, high fever, and muscle stiffness. It can also cause breathing problems or extreme drowsiness.

What to do: Talk to your doctor or pharmacist before taking these medicines together. Do not stop either medication on your own. Your doctor may adjust your doses or monitor you more closely to keep you safe.

Source: FDA-approved drug labeling via openFDA

About These Medications

tramadol — View full safety profile, side effects, and all known interactions.

trazodone — View full safety profile, side effects, and all known interactions.

Other interactions with tramadol

SEVEREalprazolamMODERATEomeprazoleMODERATElosartanMODERATEgabapentinMODERATEbupropionMODERATEfluoxetine

Other interactions with trazodone

SEVEREoxycodoneMODERATElosartanMODERATEwarfarinMODERATEclopidogrelMILDibuprofenMILDnaproxen

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.