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hydrochlorothiazide and ibuprofen — Drug Interaction

Can you take hydrochlorothiazide and ibuprofentogether? Here's what FDA data shows.

MODERATE

Interaction Found

Taking ibuprofen with hydrochlorothiazide can harm your kidneys and reduce how well your blood pressure medicine works. Your kidneys filter waste from your blood, and this combination can make them work poorly or even fail temporarily.

What to do: Talk to your doctor before taking ibuprofen while on hydrochlorothiazide. Your doctor may need to check your kidney function with blood tests. Ask about safer pain relief options like acetaminophen.

Source: FDA-approved drug labeling via openFDA

About These Medications

hydrochlorothiazide — View full safety profile, side effects, and all known interactions.

ibuprofen — View full safety profile, side effects, and all known interactions.

Other interactions with hydrochlorothiazide

MODERATElisinoprilMODERATEmetforminMODERATElosartanMODERATEpropranololMODERATEnaproxenMODERATEaspirin

Other interactions with ibuprofen

MODERATElisinoprilMODERATElosartanMODERATEsertralineMODERATEfurosemideMODERATEescitalopramMODERATEduloxetine

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.