Hydrochlorothiazide and Oxycodone: Can You Take Them Together?
Here's what FDA-approved drug labeling shows.
MODERATE
Interaction Found
Taking hydrochlorothiazide with oxycodone may cause oxycodone to stay in your body longer and be stronger than expected. This can lead to increased drowsiness, dizziness, difficulty breathing, or other opioid side effects.
What to do: Tell your doctor you take both medications. Do not change your doses or stop taking either drug without talking to your doctor first. Watch for unusual drowsiness or breathing problems and report them right away.
Source: FDA-approved drug labeling via openFDA
About These Medications
Hydrochlorothiazide — View full safety profile, side effects, and all known interactions.
Oxycodone — View full safety profile, side effects, and all known interactions.
Other interactions with Hydrochlorothiazide
Other interactions with Oxycodone
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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.