Ibuprofen and Venlafaxine: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking ibuprofen with venlafaxine may increase your risk of stomach bleeding and ulcers. This happens because both drugs can irritate your stomach lining. Venlafaxine also affects how your body processes blood thinners, which increases bleeding risk.

What to do: Talk to your doctor or pharmacist before taking ibuprofen with venlafaxine. They may suggest a safer pain reliever like acetaminophen instead. Never stop taking venlafaxine without talking to your doctor first.

Source: FDA-approved drug labeling via openFDA

About These Medications

Ibuprofen — View full safety profile, side effects, and all known interactions.

Venlafaxine — View full safety profile, side effects, and all known interactions.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.