Sertraline and Venlafaxine: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking sertraline and venlafaxine together may increase your risk of bleeding, especially in your stomach. This happens because both drugs affect how your blood clots. The risk gets higher if you also take aspirin or similar pain medicines.

What to do: Talk to your doctor about this interaction. Don't stop taking either drug without asking your doctor first. Tell your doctor if you take aspirin or other pain relievers. Watch for signs of bleeding like unusual bruising, nosebleeds, or vomiting blood.

Source: FDA-approved drug labeling via openFDA

About These Medications

Sertraline — View full safety profile, side effects, and all known interactions.

Venlafaxine — View full safety profile, side effects, and all known interactions.

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.