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Potential Drug Interactions (10)

Based on known supplement-drug interactions from FDA and NIH data. Always consult your healthcare provider.

• severe

  vitamin k + Warfarin

  Vitamin K directly counteracts warfarin's mechanism of action (inhibiting vitamin K-dependent clotting factors).

  Maintain consistent vitamin K intake. Do not start or stop supplements without consulting your doctor.

• moderate

  calcium + Tetracycline antibiotics

  Calcium binds tetracyclines in the gut, reducing antibiotic absorption by up to 50%.

  Separate doses by at least 2 hours.

• moderate

  calcium + Fluoroquinolone antibiotics

  Calcium chelates fluoroquinolones, significantly reducing their absorption.

  Take fluoroquinolones 2 hours before or 6 hours after calcium supplements.

• moderate

  calcium + Levothyroxine

  Calcium reduces absorption of thyroid hormone replacement.

  Separate doses by at least 4 hours.

• moderate

  calcium + Bisphosphonates

  Calcium impairs absorption of bisphosphonates used for osteoporosis.

  Take bisphosphonates at least 30 minutes before calcium.

• moderate

  magnesium + Fluoroquinolone antibiotics

  Magnesium chelates fluoroquinolones, reducing their absorption and effectiveness.

  Take fluoroquinolones 2 hours before or 6 hours after magnesium.

• moderate

  magnesium + Bisphosphonates

  Magnesium reduces absorption of bisphosphonates.

  Separate doses by at least 2 hours.

• moderate

  vitamin d + Digoxin

  Vitamin D increases calcium absorption, which can increase the risk of digoxin toxicity (arrhythmias).

  Monitor calcium and digoxin levels.

• moderate

  vitamin e + Anticoagulants

  High-dose vitamin E (>400 IU) may inhibit platelet aggregation and enhance anticoagulant effects.

  Avoid high-dose vitamin E with blood thinners.

• mild

  vitamin d + Thiazide diuretics

  Both vitamin D and thiazides increase calcium levels, risking hypercalcemia.

  Monitor calcium levels periodically.