Oxycodone: Uses, Side Effects, and Drug Interactions
Brand names: Oxycodone Hydrochloride
# Understanding Oxycodone Oxycodone is a strong pain reliever that doctors prescribe to help people manage moderate to severe pain. It works by changing how your body feels and responds to pain. Doctors might prescribe oxycodone after surgery, for cancer pain, or for other serious pain conditions that other medicines haven't helped. This medicine is a type of opioid, which is a powerful drug that requires careful use and monitoring by a healthcare provider. Because oxycodone is very strong, it comes with important safety warnings. The biggest risks are addiction, overdose, and death, especially if you take more than prescribed or mix it with other drugs like alcohol or certain medications. Never share your oxycodone with anyone else, and always tell your doctor about all medicines and supplements you're taking, since some can be dangerous when combined with oxycodone. Common side effects include drowsiness, constipation, and nausea. If you feel confused, have trouble breathing, or experience other serious symptoms, get medical help right away. Only use oxycodone exactly as your doctor directs, and keep it stored safely away from children and others.
Known Interactions (7)
Taking Oxycodone with other medications?
Check Oxycodone against any other medication — the form below is already pre-filled.
Check Now ↓Most Reported Side Effects (FAERS)
- DRUG DEPENDENCE102,988 reports
- PAIN68,747 reports
- OVERDOSE59,089 reports
- EMOTIONAL DISTRESS50,106 reports
- DRUG WITHDRAWAL SYNDROME38,330 reports
- DEATH33,849 reports
- DEPENDENCE22,767 reports
- NAUSEA19,577 reports
- DRUG INEFFECTIVE18,577 reports
- TOXICITY TO VARIOUS AGENTS18,317 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (3)
- Class II
Amerisource Health Services LLC · January 14, 2026
Oxycodone Hydrochloride Tablets, USP (CII), 5 mg, 100-Count (10 x 10) blister cards per carton, Rx Only, The drug product contained in this package is from NDC # 10702-018, KVK-Tech Inc. DistributeDefective container: card seal defects (weak/non-existent seals), leading to the tablets falling out of their cavities.
- Class II
SpecGx, LLC · December 16, 2025
Oxycodone and Acetaminophen CII Tablets USP, 10mg/325 mg, 100 tablets, Rx only, SpecGx LLC, Webster Groves, MO 63119, NDC 0406-0523-01.Failed Tablet/Capsule Specification: There is a potential for the imprint to be missing on tablets.
- Class II
SpecGx, LLC · December 16, 2025
Oxycodone and Acetaminophen CII Tablets USP, 7.5 mg/325 mg, 100 tablets, Rx only, SpecGx LLC, Webster Groves, MO 63119, NDC 0406-0522-01. Case label: SpecGx LLC, NDC 0406052201, Exp. 2027/03, Lot: 05Failed Tablet/Capsule Specification: There is a potential for the imprint to be missing on tablets.
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
Check interactions with Oxycodone:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.