oxycodone

Brand names: Oxycodone Hydrochloride

# Understanding Oxycodone Oxycodone is a strong pain reliever that doctors prescribe to help people manage moderate to severe pain. It works by changing how your body feels and responds to pain. Doctors might prescribe oxycodone after surgery, for cancer pain, or for other serious pain conditions that other medicines haven't helped. This medicine is a type of opioid, which is a powerful drug that requires careful use and monitoring by a healthcare provider. Because oxycodone is very strong, it comes with important safety warnings. The biggest risks are addiction, overdose, and death, especially if you take more than prescribed or mix it with other drugs like alcohol or certain medications. Never share your oxycodone with anyone else, and always tell your doctor about all medicines and supplements you're taking, since some can be dangerous when combined with oxycodone. Common side effects include drowsiness, constipation, and nausea. If you feel confused, have trouble breathing, or experience other serious symptoms, get medical help right away. Only use oxycodone exactly as your doctor directs, and keep it stored safely away from children and others.

Known Interactions

7 DRUG INTERACTIONS Table 1 includes clinically significant drug interactions with oxycodone hydrochloride. Table 1: Clinically Significant Drug Interactions with Oxycodone Hydrochloride Inhibitors of CYP3A4 and CYP2D6 Clinical Impact: The concomitant use of oxycodone hydrochloride and CYP3A4 inhibitors can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects. These effects could be more pronounced with concomitant use of oxycodone hydrochloride and CYP2D6 and CYP3A4 inhibitors, particularly when an inhibitor is added after a stable dose of oxycodone hydrochloride is achieved [see Warnings and Precautions (5.3)] . After stopping a CYP3A4 inhibitor, as the effects of the inhibitor decline, the oxycodone plasma concentration will decrease [see Clinical Pharmacology (12.3)] , resulting in decreased opioid efficacy or a withdrawal syndrome in patients who had developed physical dependence to oxycodone. Intervention: If concomitant use is necess

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DRUG DEPENDENCE102,988 reports
  • PAIN68,747 reports
  • OVERDOSE59,089 reports
  • EMOTIONAL DISTRESS50,106 reports
  • DRUG WITHDRAWAL SYNDROME38,330 reports
  • DEATH33,849 reports
  • DEPENDENCE22,767 reports
  • NAUSEA19,577 reports
  • DRUG INEFFECTIVE18,577 reports
  • TOXICITY TO VARIOUS AGENTS18,317 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with oxycodone:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.