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omeprazole and oxycodone — Drug Interaction

Can you take omeprazole and oxycodonetogether? Here's what FDA data shows.

MODERATE

Interaction Found

Omeprazole can make oxycodone stay in your body longer and stronger than expected. This could cause too much pain relief, drowsiness, or other side effects from the oxycodone.

What to do: Talk to your doctor or pharmacist about taking these medicines together. Do not stop either medication on your own. Your doctor may adjust your oxycodone dose or monitor you more closely.

Source: FDA-approved drug labeling via openFDA

About These Medications

omeprazole — View full safety profile, side effects, and all known interactions.

oxycodone — View full safety profile, side effects, and all known interactions.

Other interactions with omeprazole

MODERATElevothyroxineMODERATEtramadolMODERATEpantoprazoleMODERATEbupropionMODERATEduloxetineMODERATEwarfarin

Other interactions with oxycodone

SEVEREgabapentinSEVEREtramadolSEVEREtrazodoneSEVEREalprazolamMODERATElosartanMODERATEcyclobenzaprine

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.