Oxycodone and Tramadol: Can You Take Them Together?
Here's what FDA-approved drug labeling shows.
SEVERE
Interaction Found
Taking oxycodone and tramadol together can be dangerous. Both drugs affect how your brain handles a chemical called serotonin. When combined, they can cause serotonin syndrome (confusion, rapid heartbeat, muscle rigidity) or opioid toxicity (trouble breathing, loss of consciousness).
What to do: Tell your doctor immediately if you take both medications. Do not stop either drug on your own. Your doctor may adjust your doses or switch you to safer alternatives.
Source: FDA-approved drug labeling via openFDA
About These Medications
Other interactions with Oxycodone
Other interactions with Tramadol
Check interactions with other medications:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.