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oxycodone and tramadol — Drug Interaction
Can you take oxycodone and tramadoltogether? Here's what FDA data shows.
SEVERE
Interaction Found
Taking oxycodone and tramadol together can be dangerous. Both drugs affect how your brain handles a chemical called serotonin. When combined, they can cause serotonin syndrome (confusion, rapid heartbeat, muscle rigidity) or opioid toxicity (trouble breathing, loss of consciousness).
What to do: Tell your doctor immediately if you take both medications. Do not stop either drug on your own. Your doctor may adjust your doses or switch you to safer alternatives.
Source: FDA-approved drug labeling via openFDA
About These Medications
Other interactions with oxycodone
Other interactions with tramadol
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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.