Diclofenac and Hydrochlorothiazide: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking diclofenac with hydrochlorothiazide together may harm your kidneys and affect your body's salt and water balance. This combination can cause acute kidney injury, which means your kidneys may stop working properly.

What to do: Talk to your doctor before taking these medicines together. Your doctor may monitor your blood pressure, kidney function, and electrolytes with blood tests. Do not stop either medicine without talking to your doctor first.

Source: FDA-approved drug labeling via openFDA

About These Medications

Diclofenac — View full safety profile, side effects, and all known interactions.

Hydrochlorothiazide — View full safety profile, side effects, and all known interactions.

Other interactions with Diclofenac

SEVEREwarfarinMODERATElosartanMODERATEescitalopramMODERATEsertralineMODERATEnaproxen

Other interactions with Hydrochlorothiazide

MODERATElisinoprilMODERATEmetforminMODERATEmeloxicamMODERATEoxycodoneMODERATElosartanMODERATEibuprofen

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.