Diclofenac and Duloxetine: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

When diclofenac and duloxetine are taken together, your body may not break down duloxetine properly. This could cause duloxetine to build up to higher levels in your blood, increasing the risk of side effects like dizziness, nausea, or drowsiness.

What to do: Tell your doctor that you take both medicines. Do not stop either medication on your own. Your doctor may adjust your doses or monitor you more carefully to keep you safe.

Source: FDA-approved drug labeling via openFDA

About These Medications

Diclofenac — View full safety profile, side effects, and all known interactions.

Duloxetine — View full safety profile, side effects, and all known interactions.

Other interactions with Diclofenac

SEVEREwarfarinMODERATEhydrochlorothiazideMODERATElosartanMODERATEescitalopramMODERATEsertralineMODERATEnaproxen

Other interactions with Duloxetine

MODERATEomeprazoleMODERATEtramadolMODERATEmeloxicamMODERATEsertralineMODERATEibuprofenMODERATEfluoxetine

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.