Doxycycline and Simvastatin: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking doxycycline with simvastatin can increase levels of simvastatin in your body. This raises the risk of muscle problems, including serious muscle damage called rhabdomyolysis.

What to do: Tell your doctor if you take both medicines. Your doctor may need to adjust your simvastatin dose or monitor you more closely for muscle pain or weakness. Do not stop either medicine without talking to your doctor first.

Source: FDA-approved drug labeling via openFDA

About These Medications

Doxycycline — View full safety profile, side effects, and all known interactions.

Simvastatin — View full safety profile, side effects, and all known interactions.

Other interactions with Doxycycline

MODERATElosartanMODERATEwarfarinMODERATEamoxicillinMODERATEaspirin

Other interactions with Simvastatin

MODERATEwarfarinMODERATEatorvastatinMODERATEamlodipineMODERATErosuvastatinMODERATEpravastatin

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.