Doxycycline and Trazodone: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Doxycycline may increase the effects of trazodone, a sleep medication. This could cause extra drowsiness, dizziness, or difficulty concentrating. Both drugs can make you feel sleepy, and together they might make this worse.

What to do: Tell your doctor you take both medicines. Don't stop either medication on your own. Your doctor may adjust your trazodone dose or watch you more closely. Avoid driving or operating machinery until you know how these drugs affect you together.

Source: FDA-approved drug labeling via openFDA

About These Medications

Doxycycline — View full safety profile, side effects, and all known interactions.

Trazodone — View full safety profile, side effects, and all known interactions.

Other interactions with Doxycycline

MODERATEsimvastatinMODERATElosartanMODERATEwarfarinMODERATEpravastatinMODERATEfluoxetineMODERATEtramadol

Other interactions with Trazodone

SEVEREoxycodoneMODERATEwarfarinMODERATElosartanMODERATEtramadolMILDibuprofenMILDnaproxen

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.