Fluoxetine and Naproxen: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking fluoxetine with naproxen increases your risk of bleeding. Naproxen is a pain reliever that can thin your blood when combined with fluoxetine, an antidepressant. This may cause unusual bruising, bleeding gums, or other bleeding problems.

What to do: Talk to your doctor or pharmacist about this combination. Do not stop taking either medication on your own. Your doctor may suggest a different pain reliever or monitor you more closely while taking both drugs together.

Source: FDA-approved drug labeling via openFDA

About These Medications

Fluoxetine — View full safety profile, side effects, and all known interactions.

Naproxen — View full safety profile, side effects, and all known interactions.

Other interactions with Fluoxetine

MODERATEibuprofenMODERATElosartanMODERATEmetoprololMODERATEsertralineMODERATEtramadolMODERATEvenlafaxine

Other interactions with Naproxen

SEVEREwarfarinMODERATEpropranololMODERATEsertralineMODERATEvenlafaxineMODERATEaspirinMILDtrazodone

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.