Naproxen: Uses, Side Effects, and Drug Interactions

Brand names: Naproxen

# Naproxen: What You Need to Know Naproxen is a common pain reliever that doctors use to reduce pain, fever, and swelling caused by conditions like headaches, muscle aches, arthritis, and menstrual cramps. It works by lowering the amount of substances in your body that cause inflammation and pain. Many people use naproxen because it can provide longer-lasting relief than some other over-the-counter pain medicines. You can buy naproxen under brand names like Aleve, or your doctor might prescribe it if you need a stronger dose. While naproxen is helpful for many people, it's important to use it safely. Never take more than the recommended dose, and don't use it for longer than directed without talking to your doctor. Be especially careful if you take blood-thinning medications like warfarin, since naproxen can increase your risk of serious bleeding. Also tell your doctor about all the other medicines you're taking, because naproxen can interact with certain drugs. If you have heart disease, high blood pressure, kidney problems, or a history of stomach ulcers, talk to your doctor before using naproxen, as it may not be safe for you.

Known Interactions (18)

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Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE20,368 reports
  • PAIN12,236 reports
  • FATIGUE11,327 reports
  • NAUSEA10,614 reports
  • ARTHRALGIA10,233 reports
  • HEADACHE9,099 reports
  • OFF LABEL USE8,572 reports
  • DIARRHOEA8,288 reports
  • DIZZINESS7,794 reports
  • VOMITING7,320 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Recent Recalls (2)

Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.

Supplement Interactions (1)

These dietary supplements may interact with Naproxen. Always consult your healthcare provider.

  • moderate
    ginkgo biloba

    Additive antiplatelet effects increase bleeding risk.

    Avoid prolonged concurrent use.

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.