naproxen

Brand names: Naproxen

# Naproxen: What You Need to Know Naproxen is a common pain reliever that doctors use to reduce pain, fever, and swelling caused by conditions like headaches, muscle aches, arthritis, and menstrual cramps. It works by lowering the amount of substances in your body that cause inflammation and pain. Many people use naproxen because it can provide longer-lasting relief than some other over-the-counter pain medicines. You can buy naproxen under brand names like Aleve, or your doctor might prescribe it if you need a stronger dose. While naproxen is helpful for many people, it's important to use it safely. Never take more than the recommended dose, and don't use it for longer than directed without talking to your doctor. Be especially careful if you take blood-thinning medications like warfarin, since naproxen can increase your risk of serious bleeding. Also tell your doctor about all the other medicines you're taking, because naproxen can interact with certain drugs. If you have heart disease, high blood pressure, kidney problems, or a history of stomach ulcers, talk to your doctor before using naproxen, as it may not be safe for you.

Known Interactions

7 DRUG INTERACTIONS See Table 1 for clinically significant drug interactions with naproxen. Table 1: Clinically Significant Drug Interactions with naproxen Drugs That Interfere with Hemostasis Clinical Impact: • Naproxen and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of naproxen and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. • Serotonin release by platelets plays an important role in hemostasis. Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone. Intervention: Monitor patients with concomitant use of naproxen tablets or naproxen sodium tablets with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs) for signs of blee

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • DRUG INEFFECTIVE20,368 reports
  • PAIN12,236 reports
  • FATIGUE11,327 reports
  • NAUSEA10,614 reports
  • ARTHRALGIA10,233 reports
  • HEADACHE9,099 reports
  • OFF LABEL USE8,572 reports
  • DIARRHOEA8,288 reports
  • DIZZINESS7,794 reports
  • VOMITING7,320 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with naproxen:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.