tramadol
Brand names: TRAMADOL HYDROCHLORIDE
# Overview of Tramadol Tramadol is a pain medication that doctors prescribe to help people manage moderate pain. It works by changing how your body feels and responds to pain signals in your brain and spinal cord. People use tramadol after surgery, for injuries, or for ongoing pain conditions. It comes in different forms, including extended-release tablets that work throughout the day. When taking tramadol, it's important to follow your doctor's instructions carefully and take only the amount prescribed. This medication can be habit-forming, so it should only be used as directed and not shared with others. You should tell your doctor about all other medicines you take, since tramadol can interact with certain drugs and cause serious side effects. Common side effects include dizziness, drowsiness, nausea, and constipation. Never mix tramadol with alcohol, and be careful about driving or operating machinery until you know how it affects you. If you experience serious symptoms like difficulty breathing, extreme drowsiness, or severe allergic reactions, seek emergency help right away.
Known Interactions
7 DRUG INTERACTIONS Table 2 includes clinically significant drug interactions with tramadol hydrochloride extended-release tablets. Table 2: Clinically Significant Drug Interactions with Tramadol Hydrochloride Extended-Release Tablets Inhibitors of CYP2D6 Clinical Impact: The concomitant use of tramadol hydrochloride extended-release tablets and CYP2D6 inhibitors may result in an increase in the plasma concentration of tramadol and a decrease in the plasma concentration of M1, particularly when an inhibitor is added after a stable dose of tramadol hydrochloride extended-release tablets is achieved. Since M1 is a more potent µ-opioid agonist, decreased M1 exposure could result in decreased therapeutic effects, and may result in signs and symptoms of opioid withdrawal in patients who had developed physical dependence to tramadol. Increased tramadol exposure can result in increased or prolonged therapeutic effects and increased risk for serious adverse events including seizures and seroto
Source: FDA-approved drug labeling via openFDA
Most Reported Side Effects (FAERS)
- DEPENDENCE7,820 reports
- OVERDOSE3,862 reports
- VOMITING3,199 reports
- PAIN2,925 reports
- NAUSEA2,784 reports
- DRUG INEFFECTIVE2,546 reports
- HEADACHE2,306 reports
- FATIGUE2,282 reports
- OFF LABEL USE2,248 reports
- DYSPNOEA2,241 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Check interactions with tramadol:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.