Tramadol: Uses, Side Effects, and Drug Interactions
Brand names: TRAMADOL HYDROCHLORIDE
# Overview of Tramadol Tramadol is a pain medication that doctors prescribe to help people manage moderate pain. It works by changing how your body feels and responds to pain signals in your brain and spinal cord. People use tramadol after surgery, for injuries, or for ongoing pain conditions. It comes in different forms, including extended-release tablets that work throughout the day. When taking tramadol, it's important to follow your doctor's instructions carefully and take only the amount prescribed. This medication can be habit-forming, so it should only be used as directed and not shared with others. You should tell your doctor about all other medicines you take, since tramadol can interact with certain drugs and cause serious side effects. Common side effects include dizziness, drowsiness, nausea, and constipation. Never mix tramadol with alcohol, and be careful about driving or operating machinery until you know how it affects you. If you experience serious symptoms like difficulty breathing, extreme drowsiness, or severe allergic reactions, seek emergency help right away.
Known Interactions (12)
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Check Now ↓Most Reported Side Effects (FAERS)
- DEPENDENCE7,820 reports
- OVERDOSE3,862 reports
- VOMITING3,199 reports
- PAIN2,925 reports
- NAUSEA2,784 reports
- DRUG INEFFECTIVE2,546 reports
- HEADACHE2,306 reports
- FATIGUE2,282 reports
- OFF LABEL USE2,248 reports
- DYSPNOEA2,241 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (2)
- Class II
Amneal Pharmaceuticals, LLC · March 19, 2026
traMADol Hydrochloride Tablets, USP, 50 mg, 500-count bottles, Rx only, Manufactured by: Amneal Pharmaceuticals Pvt. Ltd., Ahmedabad 382220, India, Distributed by: Amneal Pharmaceuticals LLC, GlasgowFailed Impurities/Degradation Specifications: N-nitroso-desmethyl-tramadol impurity (NDSRI) was found out of the specification at 24-month stability interval during Long term stability (25¿C/60%RH).
- Class II
Rubicon Research Private Limited · April 26, 2024
traMADol Hydrochloride Tablets, USP 50 mg, 1000-count bottle, Rx Only, Distributed by: Advagen Pharma Limited, 666 Plainsboro Road Suite 605, Plainsboro, NJ, 08536, USA, Manufactured by: Rubicon ReseaPresence of Foreign Tablets: Pharmacist reported a tablet of baclofen in a bottle of 1000-count tramadol
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.