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duloxetine and naproxen — Drug Interaction

Can you take duloxetine and naproxentogether? Here's what FDA data shows.

MODERATE

Interaction Found

Taking duloxetine with naproxen (an NSAID) together increases your risk of stomach bleeding. Duloxetine affects how your blood clots, and naproxen can make this worse.

What to do: Talk to your doctor before taking naproxen or other NSAIDs while on duloxetine. Your doctor may suggest a different pain reliever or monitor you more closely. Never stop duloxetine without talking to your doctor first.

Source: FDA-approved drug labeling via openFDA

About These Medications

duloxetine — View full safety profile, side effects, and all known interactions.

naproxen — View full safety profile, side effects, and all known interactions.

Other interactions with duloxetine

SEVEREwarfarinMODERATEomeprazoleMODERATEibuprofenMODERATEfluoxetineMODERATEaspirinMILDlorazepam

Other interactions with naproxen

MODERATElisinoprilMODERATElosartanMODERATEhydrochlorothiazideMODERATEsertralineMODERATEfurosemideMILDgabapentin

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.