Duloxetine and Tramadol: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking duloxetine and tramadol together can increase duloxetine levels in your body, which may cause more side effects like dizziness, nausea, or drowsiness. This combination may also increase bleeding risk, especially if you take blood thinners or NSAIDs like ibuprofen.

What to do: Talk to your doctor or pharmacist before taking these medicines together. Do not stop taking either medication on your own. Your doctor may adjust your doses or monitor you more closely.

Source: FDA-approved drug labeling via openFDA

About These Medications

Duloxetine — View full safety profile, side effects, and all known interactions.

Tramadol — View full safety profile, side effects, and all known interactions.

Other interactions with Duloxetine

SEVEREwarfarinMODERATEomeprazoleMODERATEsertralineMODERATEibuprofenMODERATEfluoxetineMODERATEnaproxen

Other interactions with Tramadol

MODERATEtrazodoneMODERATEwarfarinMODERATEomeprazoleMODERATElosartanMODERATEgabapentinMODERATEamoxicillin

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.