duloxetine

Brand names: Duloxetine Delayed-Release

# Overview of Duloxetine Duloxetine is a prescription medicine used to treat depression, anxiety, and certain types of chronic pain conditions like fibromyalgia and nerve pain. It works by helping to balance chemicals in the brain called serotonin and norepinephrine, which affect mood and how your body handles pain. The medicine comes as a delayed-release capsule, which means it's designed to release slowly in your body so it works over time. Doctors typically start patients on a lower dose and may increase it based on how well it works and how you feel. When taking duloxetine, it's important to know some key safety points. This medication can interact with other drugs, especially certain medicines that affect how your liver breaks down the medicine, so always tell your doctor about all medications you're taking. Common side effects may include nausea, dizziness, and dry mouth. You should not suddenly stop taking duloxetine without talking to your doctor first, because stopping abruptly can cause problems. Additionally, this medicine may increase the risk of bleeding, especially if you take blood thinners, and it's not recommended for pregnant women without discussing the risks with your doctor. If you experience any concerning symptoms or have questions, contact your healthcare provider right away.

Known Interactions

7 DRUG INTERACTIONS Both CYP1A2 and CYP2D6 are responsible for duloxetine metabolism. Potent inhibitors of CYP1A2 should be avoided ( 7.1 ) Potent inhibitors of CYP2D6 may increase Duloxetine delayed-release capsules concentrations ( 7.2 ) Duloxetine delayed-release capsules is a moderate inhibitor of CYP2D6 ( 7.9 ) 7.1 Inhibitors of CYP1A2 When duloxetine 60 mg was co-administered with fluvoxamine 100 mg, a potent CYP1A2 inhibitor, to male subjects (n=14) duloxetine AUC was increased approximately 6-fold, the C max was increased about 2.5-fold, and duloxetine t 1/2 was increased approximately 3-fold. Other drugs that inhibit CYP1A2 metabolism include cimetidine and quinolone antimicrobials such as ciprofloxacin and enoxacin [see Warnings and Precautions (5.12) ]. 7.2 Inhibitors of CYP2D6 Concomitant use of duloxetine (40 mg once daily) with paroxetine (20 mg once daily) increased the concentration of duloxetine AUC by about 60%, and greater degrees of inhibition are expected with high

Source: FDA-approved drug labeling via openFDA

Most Reported Side Effects (FAERS)

  • NAUSEA17,482 reports
  • FATIGUE15,599 reports
  • DRUG INEFFECTIVE13,691 reports
  • HEADACHE13,361 reports
  • DIZZINESS13,138 reports
  • PAIN12,077 reports
  • DIARRHOEA9,710 reports
  • INSOMNIA9,701 reports
  • OFF LABEL USE9,531 reports
  • ANXIETY9,526 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Check interactions with duloxetine:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.