Duloxetine: Uses, Side Effects, and Drug Interactions
Brand names: Duloxetine Delayed-Release
# Overview of Duloxetine Duloxetine is a prescription medicine used to treat depression, anxiety, and certain types of chronic pain conditions like fibromyalgia and nerve pain. It works by helping to balance chemicals in the brain called serotonin and norepinephrine, which affect mood and how your body handles pain. The medicine comes as a delayed-release capsule, which means it's designed to release slowly in your body so it works over time. Doctors typically start patients on a lower dose and may increase it based on how well it works and how you feel. When taking duloxetine, it's important to know some key safety points. This medication can interact with other drugs, especially certain medicines that affect how your liver breaks down the medicine, so always tell your doctor about all medications you're taking. Common side effects may include nausea, dizziness, and dry mouth. You should not suddenly stop taking duloxetine without talking to your doctor first, because stopping abruptly can cause problems. Additionally, this medicine may increase the risk of bleeding, especially if you take blood thinners, and it's not recommended for pregnant women without discussing the risks with your doctor. If you experience any concerning symptoms or have questions, contact your healthcare provider right away.
Known Interactions (17)
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Check Now ↓Most Reported Side Effects (FAERS)
- NAUSEA17,482 reports
- FATIGUE15,599 reports
- DRUG INEFFECTIVE13,691 reports
- HEADACHE13,361 reports
- DIZZINESS13,138 reports
- PAIN12,077 reports
- DIARRHOEA9,710 reports
- INSOMNIA9,701 reports
- OFF LABEL USE9,531 reports
- ANXIETY9,526 reports
Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.
Recent Recalls (5)
- Class II
Breckenridge Pharmaceutical, Inc. · June 4, 2026
Duloxetine Delayed-Release Capsules, USP, 30mg, 1000 Capsule bottles, Rx only, Manufactured. by: Towa Pharmaceutical Europe, S.L. Martorelles, (Barcelona), Spain, Distributed by: Breckenridge PharmaceCGMP Deviations: Presence of N-nitroso-duloxetine impurity above FDA recommended interim limit
- Class II
Breckenridge Pharmaceutical, Inc. · June 4, 2026
Duloxetine Delayed-Release Capsules, USP, 60mg, packaged in a) 90 Capsules (NDC 51991-748-90); b) 1000 Capsules (51991-748-10), Rx Only, Mfr. by: Towa Pharmaceutical Europe, S.L. Martorelles, (BarceloCGMP Deviations: Presence of N-nitroso-duloxetine impurity above FDA recommended interim limit
- Class II
Asclemed USA Inc. · May 14, 2026
Duloxetine DR Capsules, 30 mg, 30 count bottles, Rx, Relabeled by: Enovachem Pharmaceuticals, Torrance, CA 90501, NDC 76420-634-30, Marketed by: Ajanta Pharma USA Inc.CGMP Deviations; presence of Nitrosamine Drug Substance Related Impurity (NDSRI), N-nitroso-duloxetine, above the FDA acceptable intake limit.
- Class II
Ajanta Pharma Ltd. · April 29, 2026
Duloxetine Delayed-Release Capsules, 60 mg, Rx Only, 30 capsules, Marketed by: Ajanta Pharma USA Inc., Bridgewater, NJ 08807, Made in India, NDC 27241-099-03CGMP Deviations: Presence of N-nitroso-Duloxetine impurity above FDA recommended limit of 0.83 ppm, identified at the 12-month and 18-month long-term stability intervals.
- Class II
Ajanta Pharma Ltd. · April 29, 2026
Duloxetine Delayed-Release Capsules, 20 mg, Rx Only, 60 capsules, Marketed by: Ajanta Pharma USA Inc., Bridgewater, NJ 08807, Made in India, NDC 27241-097-06.CGMP Deviations: Presence of N-nitroso-Duloxetine impurity above FDA recommended limit of 0.83 ppm, identified at the 12-month and 18-month long-term stability intervals.
Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.
Check interactions with Duloxetine:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.