Duloxetine: Uses, Side Effects, and Drug Interactions

Brand names: Duloxetine Delayed-Release

# Overview of Duloxetine Duloxetine is a prescription medicine used to treat depression, anxiety, and certain types of chronic pain conditions like fibromyalgia and nerve pain. It works by helping to balance chemicals in the brain called serotonin and norepinephrine, which affect mood and how your body handles pain. The medicine comes as a delayed-release capsule, which means it's designed to release slowly in your body so it works over time. Doctors typically start patients on a lower dose and may increase it based on how well it works and how you feel. When taking duloxetine, it's important to know some key safety points. This medication can interact with other drugs, especially certain medicines that affect how your liver breaks down the medicine, so always tell your doctor about all medications you're taking. Common side effects may include nausea, dizziness, and dry mouth. You should not suddenly stop taking duloxetine without talking to your doctor first, because stopping abruptly can cause problems. Additionally, this medicine may increase the risk of bleeding, especially if you take blood thinners, and it's not recommended for pregnant women without discussing the risks with your doctor. If you experience any concerning symptoms or have questions, contact your healthcare provider right away.

Known Interactions (11)

Taking Duloxetine with other medications?

Check Duloxetine against any other medication — the form below is already pre-filled.

Check Now ↓

Most Reported Side Effects (FAERS)

  • NAUSEA17,482 reports
  • FATIGUE15,599 reports
  • DRUG INEFFECTIVE13,691 reports
  • HEADACHE13,361 reports
  • DIZZINESS13,138 reports
  • PAIN12,077 reports
  • DIARRHOEA9,710 reports
  • INSOMNIA9,701 reports
  • OFF LABEL USE9,531 reports
  • ANXIETY9,526 reports

Source: FDA Adverse Event Reporting System (FAERS). Voluntary reports do not establish causation.

Recent Recalls (5)

Source: FDA (openFDA Drug Enforcement). Voluntary and mandated recalls affecting this drug.

Check interactions with Duloxetine:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.