← Check other medications

duloxetine and fluoxetine — Drug Interaction

Can you take duloxetine and fluoxetinetogether? Here's what FDA data shows.

MODERATE

Interaction Found

Taking duloxetine with fluoxetine together can cause too much duloxetine to build up in your body. This happens because fluoxetine slows down how your body breaks down duloxetine. Having too much duloxetine in your system can increase side effects like dizziness, nausea, or drowsiness.

What to do: Talk to your doctor or pharmacist before taking these medications together. Your doctor may need to adjust your doses or monitor you more closely. Do not stop either medication on your own.

Source: FDA-approved drug labeling via openFDA

About These Medications

duloxetine — View full safety profile, side effects, and all known interactions.

fluoxetine — View full safety profile, side effects, and all known interactions.

Other interactions with duloxetine

SEVEREwarfarinMODERATEomeprazoleMODERATEibuprofenMODERATEnaproxenMODERATEaspirinMILDlorazepam

Other interactions with fluoxetine

MODERATEmetoprololMODERATElosartanMODERATEsertralineMODERATEbupropionMODERATEtramadolMODERATEibuprofen

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.