Duloxetine and Sertraline: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking duloxetine and sertraline together can increase the amount of duloxetine in your body. This may raise your risk of bleeding, especially if you also take blood thinners, aspirin, or NSAIDs like ibuprofen.

What to do: Tell your doctor about all medicines you take. Do not stop either medication without talking to your doctor first. Ask your doctor if you need to avoid aspirin or NSAIDs while taking these drugs together.

Source: FDA-approved drug labeling via openFDA

About These Medications

Duloxetine — View full safety profile, side effects, and all known interactions.

Sertraline — View full safety profile, side effects, and all known interactions.

Other interactions with Duloxetine

SEVEREwarfarinMODERATEomeprazoleMODERATEtramadolMODERATEibuprofenMODERATEfluoxetineMODERATEnaproxen

Other interactions with Sertraline

MODERATEvenlafaxineMODERATEwarfarinMODERATElosartanMODERATElevothyroxineMODERATEatenololMODERATEbupropion

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.