Duloxetine and Ibuprofen: Can You Take Them Together?
Here's what FDA-approved drug labeling shows.
MODERATE
Interaction Found
Taking ibuprofen with duloxetine increases your risk of bleeding, especially in your stomach and intestines. Duloxetine affects how your blood clots, and ibuprofen increases this effect. This combination can cause serious bleeding problems.
What to do: Talk to your doctor or pharmacist before taking ibuprofen while on duloxetine. Ask about safer pain relief options. If you must take ibuprofen, use the lowest dose for the shortest time. Watch for signs of bleeding like unusual bruising, bloody stools, or vomiting blood.
Source: FDA-approved drug labeling via openFDA
About These Medications
Duloxetine — View full safety profile, side effects, and all known interactions.
Ibuprofen — View full safety profile, side effects, and all known interactions.
Other interactions with Duloxetine
Other interactions with Ibuprofen
Check interactions with other medications:
SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.