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duloxetine and ibuprofen — Drug Interaction

Can you take duloxetine and ibuprofentogether? Here's what FDA data shows.

MODERATE

Interaction Found

Taking ibuprofen with duloxetine increases your risk of bleeding, especially in your stomach and intestines. Duloxetine affects how your blood clots, and ibuprofen increases this effect. This combination can cause serious bleeding problems.

What to do: Talk to your doctor or pharmacist before taking ibuprofen while on duloxetine. Ask about safer pain relief options. If you must take ibuprofen, use the lowest dose for the shortest time. Watch for signs of bleeding like unusual bruising, bloody stools, or vomiting blood.

Source: FDA-approved drug labeling via openFDA

About These Medications

duloxetine — View full safety profile, side effects, and all known interactions.

ibuprofen — View full safety profile, side effects, and all known interactions.

Other interactions with duloxetine

SEVEREwarfarinMODERATEomeprazoleMODERATEfluoxetineMODERATEnaproxenMODERATEaspirinMILDlorazepam

Other interactions with ibuprofen

MODERATElisinoprilMODERATElosartanMODERATEhydrochlorothiazideMODERATEsertralineMODERATEfurosemideMODERATEescitalopram

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SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.