Oxycodone and Sertraline: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Sertraline can increase the amount of oxycodone in your body. This means oxycodone could work stronger and longer than expected, which could cause dizziness, drowsiness, or breathing problems.

What to do: Tell your doctor you take both medicines. Your doctor may adjust your oxycodone dose or monitor you more closely. Never stop either medicine without talking to your doctor first.

Source: FDA-approved drug labeling via openFDA

About These Medications

Oxycodone — View full safety profile, side effects, and all known interactions.

Sertraline — View full safety profile, side effects, and all known interactions.

Other interactions with Oxycodone

SEVEREtramadolSEVEREtrazodoneMODERATEvenlafaxineMODERATEomeprazoleMODERATEhydrochlorothiazideMODERATElosartan

Other interactions with Sertraline

MODERATEvenlafaxineMODERATEwarfarinMODERATEtramadolMODERATElosartanMODERATElevothyroxineMODERATEatenolol

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.