Oxycodone and Venlafaxine: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Venlafaxine can increase how much oxycodone stays in your body. This means oxycodone could work longer and stronger than expected, which could be dangerous.

What to do: Tell your doctor you're taking both medicines. Your doctor may need to adjust your oxycodone dose or watch you more closely for side effects like drowsiness, dizziness, or difficulty breathing. Don't stop either medicine without talking to your doctor first.

Source: FDA-approved drug labeling via openFDA

About These Medications

Oxycodone — View full safety profile, side effects, and all known interactions.

Venlafaxine — View full safety profile, side effects, and all known interactions.

Other interactions with Oxycodone

SEVEREtramadolSEVEREtrazodoneSEVEREgabapentinMODERATEomeprazoleMODERATEhydrochlorothiazideMODERATElosartan

Other interactions with Venlafaxine

MODERATEwarfarinMODERATEmetoprololMODERATEescitalopramMODERATEsertralineMODERATEbupropionMODERATEibuprofen

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.