Sertraline and Tramadol: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking sertraline with tramadol can cause tramadol to build up in your body to higher levels than normal. This happens because sertraline slows down how your body breaks down tramadol. Too much tramadol in your system can be dangerous.

What to do: Talk to your doctor or pharmacist about taking these medications together. Do not stop either medication on your own. Your doctor may adjust your tramadol dose or monitor you more closely to keep you safe.

Source: FDA-approved drug labeling via openFDA

About These Medications

Sertraline — View full safety profile, side effects, and all known interactions.

Tramadol — View full safety profile, side effects, and all known interactions.

Other interactions with Sertraline

MODERATEvenlafaxineMODERATEwarfarinMODERATElosartanMODERATElevothyroxineMODERATEatenololMODERATEbupropion

Other interactions with Tramadol

MODERATEtrazodoneMODERATEwarfarinMODERATEvenlafaxineMODERATEomeprazoleMODERATElosartanMODERATEgabapentin

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.