Clopidogrel and Duloxetine: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking clopidogrel with duloxetine (an SNRI) increases your risk of bleeding. This happens because duloxetine makes clopidogrel work more strongly on your blood platelets, which can cause unusual or excessive bleeding.

What to do: Talk to your doctor or pharmacist about taking these two medicines together. Do not stop either medication on your own. Your doctor may monitor you more closely or adjust your doses if needed.

Source: FDA-approved drug labeling via openFDA

About These Medications

Clopidogrel — View full safety profile, side effects, and all known interactions.

Duloxetine — View full safety profile, side effects, and all known interactions.

Other interactions with Clopidogrel

SEVEREwarfarinMODERATEomeprazoleMODERATEescitalopramMODERATEpantoprazoleMODERATEibuprofenMODERATEtrazodone

Other interactions with Duloxetine

MODERATEomeprazoleMODERATEtramadolMODERATEmeloxicamMODERATEsertralineMODERATEibuprofenMODERATEfluoxetine

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.