Amoxicillin and Oxycodone: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking amoxicillin with oxycodone may cause oxycodone to stay in your body longer and work stronger than expected. This could increase side effects like drowsiness, dizziness, or difficulty breathing.

What to do: Tell your doctor you're taking both medicines. Don't change your doses on your own. Your doctor may adjust your oxycodone dose or monitor you more closely while taking amoxicillin.

Source: FDA-approved drug labeling via openFDA

About These Medications

Amoxicillin — View full safety profile, side effects, and all known interactions.

Oxycodone — View full safety profile, side effects, and all known interactions.

Other interactions with Amoxicillin

MODERATEtramadolMODERATEwarfarinMODERATEdoxycycline

Other interactions with Oxycodone

SEVEREtramadolSEVEREtrazodoneMODERATEvenlafaxineMODERATEomeprazoleMODERATEhydrochlorothiazideMODERATElosartan

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.