Fluoxetine and Oxycodone: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

SEVERE

Interaction Found

Fluoxetine can increase how much oxycodone stays in your body. This can make oxycodone work stronger and longer than expected, which is dangerous.

What to do: Tell your doctor that you take both medications. Your doctor may adjust your oxycodone dose or monitor you more closely. Do not change your medications on your own.

Source: FDA-approved drug labeling via openFDA

About These Medications

Fluoxetine — View full safety profile, side effects, and all known interactions.

Oxycodone — View full safety profile, side effects, and all known interactions.

Other interactions with Fluoxetine

MODERATEmetoprololMODERATElosartanMODERATEsertralineMODERATEtramadolMODERATEibuprofenMODERATEwarfarin

Other interactions with Oxycodone

SEVEREtramadolSEVEREtrazodoneMODERATEvenlafaxineMODERATEsertralineMODERATEomeprazoleMODERATEhydrochlorothiazide

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.