Duloxetine and Oxycodone: Can You Take Them Together?

Here's what FDA-approved drug labeling shows.

MODERATE

Interaction Found

Taking duloxetine with oxycodone together can increase the amount of duloxetine in your body. This may cause dizziness, drowsiness, confusion, or difficulty concentrating. There is also a small risk of bleeding, especially if you take aspirin or NSAIDs like ibuprofen at the same time.

What to do: Tell your doctor you take both medications. Do not stop taking either drug without talking to your doctor first. Your doctor may adjust your doses or monitor you more closely. Avoid aspirin and NSAIDs unless your doctor says it is safe.

Source: FDA-approved drug labeling via openFDA

About These Medications

Duloxetine — View full safety profile, side effects, and all known interactions.

Oxycodone — View full safety profile, side effects, and all known interactions.

Other interactions with Duloxetine

MODERATEescitalopramMODERATEfluoxetineMODERATEibuprofenMODERATEmeloxicamMILDfamotidineMILDlorazepam

Other interactions with Oxycodone

SEVEREtramadolSEVEREtrazodoneSEVEREalprazolamMODERATEsertralineMODERATEvenlafaxineMODERATEamoxicillin

Check interactions with other medications:

SafeCheck provides drug interaction information from FDA-approved product labeling (openFDA). This is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions.